Apigenin 7-beta-D-glucoside
7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS: 578-74-5
Molecular Formula: C21H20O10
Apigenin 7-beta-D-glucoside - Names and Identifiers
Apigenin 7-beta-D-glucoside - Physico-chemical Properties
| Molecular Formula | C21H20O10 |
| Molar Mass | 432.38 |
| Density | 1.642±0.06 g/cm3(Predicted) |
| Melting Point | 230-237°C |
| Boling Point | 788.9±60.0 °C(Predicted) |
| Specific Rotation(α) | (Py)-64 |
| Flash Point | 280.7°C |
| Solubility | Soluble in hot methanol, DMSO and other solvents, insoluble in petroleum ether, chloroform. |
| Vapor Presure | 3.14E-26mmHg at 25°C |
| Appearance | White crystal |
| Color | Pale Yellow to Yellow |
| BRN | 65669 |
| pKa | 6.13±0.40(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.717 |
| MDL | MFCD00016787 |
| Physical and Chemical Properties | White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from patchouli, Herba Herba, Humulus, Broussonetia leaves. |
| In vitro study | Apigenin 7-glucoside exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside specifically induces the differentiation of CD34 + cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner. |
Apigenin 7-beta-D-glucoside - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29389090 |
Apigenin 7-beta-D-glucoside - Reference
| Reference Show more | 1. Han Xing, Li Xueyan, Yang Haiyang, et al. Screening of quality control components of Chrysanthemum Water extract and its network pharmacological effects [J]. China Pharmacy, 2019, 030(023):3258-3265. 2. Tan Xiangjie, Fu Lai, Huang Mei et al. Effects of different primary processing methods on the contents of main chemical components in naked flower beads [J]. Science of tropical agriculture 2018 v.38;No.251(07):36-42. 3. Qiang Zhang, Ruiyun Huo, Yibo Ma, Shuangmei Yan petals: Optimization, kinetic, chemical compositio 4. Liu, Chanmin, et al. "Flavonoid-rich extract of Paulownia fortunei flowers attenuates diet-induced hyperlipidemia, hepatic steatosis and insulin resistance in obesity mice by AMPK pathway." Nutrients 9.9 (2017): 959.https://doi.org/10.3390/nu9090959 5. [IF=7.514] Chu-Yang Wang et al."Isolation of wheat mutants with higher grain phenolics to enhance anti-oxidant potential."Food Chem. 2020 Jan;303:125363 6. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 7. [IF=5.645] Qiang Zhang et al."A novel microwave-assisted steam distillation approach for separation of essential oil from tree peony (Paeonia suffruticosa Andrews) petals: Optimization, kinetic, chemical composition and antioxidant activity."Ind Crop Prod. 2020 Oct; 8. [IF=4.821] Xiangwei Chang et al."Untargeted metabolomics approach reveals the tissue-specific markers of balloon flower root (Platycodi Radix) using UPLC-Q-TOF/MS."Microchem J. 2021 Sep;168:106447 9. [IF=4.759] Fengli Chen et al."Magnetically stabilized bed packed with synthesized magnetic silicone loaded with ionic liquid particles for efficient enrichment of flavonoids from tree peony petals."J Chromatogr A. 2020 Feb;1613:460671 10. [IF=4.411] Yi Li et al."Evaluation of Anti-Inflammatory and Antioxidant Effectsof Chrysanthemum Stem and Leaf Extract on Zebrafish Inflammatory Bowel Disease Model."Molecules. 2022 Jan;27(7):2114 11. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 12. [IF=2.863] Jue Cui et al."Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells."Food Science & Nutrition |
Apigenin 7-beta-D-glucoside - Reference Information
| Plant Source: | Chrysanthemum |
| biological activity | Apigenin-7-glucoside (↑),ROS scavenger, with anti-proliferative, antioxidant activity. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: anti-tumor, anti-inflammatory, anti-virus. |
Last Update：2024-04-09 20:48:19
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